Transdermal Herbal Patch using Ocimum Gratissimum: A Review

Abstract

This research explores the development and evaluation of a herbal transdermal drug delivery system (TDDS) patch incorporating Ocimum gratissimum extract for antifungal therapy. Ocimum Gratissimum, rich in bioactive compounds such as eugenol and flavonoids, is extracted and uniformly blended into a biocompatible polymer matrix to create a medicated adhesive patch. This matrix-type. TDDS ensures the controlled, sustained release of antifungal phytochemicals through the skin, achieving therapeutic levels at the site of infection while bypassing gastrointestinal metabolism. The advantages of this approach include improved patient compliance, reduced systemic side effects, and steady plasma drug levels, making it particularly valuable for chronic or recurrent skin infections. Ultimately, this study demonstrates the potential of Ocimum gratissimum-loaded herbal patches as a safe, natural, and effective alternative in antifungal transdermal therapy, aligned with modern controlled drug delivery principles and patientcentered care.