Bioadhesive Self-Nanoemulsifying Drug Delivery Systems (BSNEDDS): A Novel Strategy to Enhance Mucosal Drug Absorption and Bioavailability
Keywords:
Bioadhesive, Self-Nanoemulsifying Drug Delivery System (SNEDDS), Mucosal Absorption, Drug Bioavailability, Nanoemulsion, Mucoadhesion, Drug Delivery, Pharmaceutical Formulation.Abstract
The development of bioadhesive self-nanoemulsifying drug delivery systems (B-SNEDDS) represents a promising approach to enhance mucosal absorption and improve drug bioavailability. This study focuses on designing and evaluating a B-SNEDDS for effective mucosal drug delivery by combining the advantages of self-nanoemulsifying drug delivery systems (SNEDDS) with bioadhesive properties. The formulation was optimized using a blend of oil, surfactant, and cosurfactant, ensuring spontaneous nanoemulsion formation upon contact with physiological fluids. Bioadhesive polymers were incorporated to enhance retention time and improve drug absorption at the mucosal site. The prepared B-SNEDDS was characterized based on droplet size, zeta potential, drug loading efficiency, and bioadhesion strength. In vitro and ex vivo studies demonstrated improved mucosal permeability and prolonged retention time compared to conventional formulations. The results suggest that B-SNEDDS can significantly enhance mucosal drug delivery, providing an effective strategy for improving the therapeutic efficacy of poorly absorbed drugs
