Topical Delivery of Sulfasalazine via Nanosponges-Loaded Hydrogels: A Novel Approach for Enhanced Psoriasis Management

Abstract

The treatment of psoriasis, a chronic skin condition, remains a significant clinical challenge. Traditional therapies often come with limitations such as systemic side effects and inadequate localized treatment. In this study, we propose the development of sulfasalazineloaded nanosponges incorporated into hydrogel matrices to enhance topical psoriasis management. The nanosponges, known for their ability to encapsulate and release drugs in a controlled manner, were synthesized using a simple method to improve the solubility and bioavailability of sulfasalazine. The hydrogel system was optimized for skin compatibility and ease of application. The in vitro release studies demonstrated sustained drug release, while ex vivo permeation studies indicated effective drug delivery across the skin layers. The formulation showed promising anti-inflammatory properties, and its ability to reduce psoriatic symptoms was evaluated through cell culture models. This novel nanosponges-hydrogel combination offers a promising approach to enhance the topical treatment of psoriasis, minimizing systemic exposure and maximizing localized therapeutic efficacy.