Posaconazole-Loaded Chitosan Transdermal Films: A Microemulsion-Based Strategy for Aspergillosis

Abstract

Posaconazole, a broad-spectrum antifungal agent, has gained prominence in the treatment of Aspergillosis. However, its clinical efficacy is often limited due to poor bioavailability and the need for frequent administration. To overcome these limitations, this study proposes the development of Posaconazole-loaded chitosan transdermal films using a microemulsion-based strategy. The microemulsion system serves as a potential carrier for enhanced drug penetration, facilitating controlled release and increasing the bioavailability of Posaconazole. Chitosan, a biocompatible and biodegradable polymer, was utilized to prepare transdermal films that exhibit favorable mechanical properties and skin permeability. The films were optimized for their drug-loading capacity, in vitro release behavior, and skin permeation profile, with the goal of improving the therapeutic efficacy of Posaconazole in the treatment of Aspergillosis. The results demonstrate that the microemulsion-based strategy significantly enhances the transdermal delivery of Posaconazole, providing a promising alternative to conventional oral or intravenous formulations. This approach holds potential for improving patient compliance and treatment outcomes for Aspergillosis.