Stimuli-Responsive Injectable Polymeric Implants (SIPI) for Sustained Drug Delivery in Chronic Disease Management

Abstract

Chronic diseases require sustained drug release systems to ensure therapeutic efficacy and patient compliance. This study focuses on the formulation and characterization of SIPI-based (StimuliResponsive Injectable Polymeric Implants) for long-term drug release in chronic disease management. SIPI implants, designed using biocompatible and biodegradable polymers, respond to physiological stimuli to achieve controlled and prolonged drug delivery. The formulation process involves polymer selection, drug loading optimization, and in-vitro release kinetics evaluation. Characterization techniques, including Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), and in-vitro biodegradation studies, are utilized to assess the physicochemical properties, stability, and release profile of the implants. The developed system demonstrates sustained drug release over extended periods, minimizing dosing frequency and improving therapeutic outcomes. The findings suggest that SIPI-based implants hold significant potential in managing chronic diseases, offering an innovative approach to enhancing patient adherence and treatment efficacy